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Nature Genetics, AUGUST 2008, VOLUME 40, NUMBER 8

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Jeffrey C Barrett, Sarah Hansoul, Dan L Nicolae, Judy H Cho, Richard H Duerr, John D Rioux, Steven R Brant, Mark S Silverberg, Kent D Taylor, M Michael Barmada, Alain Bitton, Themistocles Dassopoulos, Lisa Wu Datta, Todd Green, Anne M Griffiths, Emily O Kistner, Michael T Murtha, Miguel D Regueiro, Jerome I Rotter, L Philip Schumm, A Hillary Steinhart, Stephan R Targan, Ramnik J Xavier, the NIDDK IBD Genetics Consortium, CÃ©cile Libioulle, Cynthia Sandor, Mark Lathrop, Jacques Belaiche, Olivier Dewit, Ivo Gut, Simon Heath, Debby Laukens, Myriam Mni, Paul Rutgeerts, AndrÃ© Van Gossum, Diana Zelenika, Denis Franchimont, Jean-Pierre Hugot, Martine de Vos, Severine Vermeire, Edouard Louis, the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Lon R Cardon, Carl A Anderson, Hazel Drummond, Elaine Nimmo, Tariq Ahmad, Natalie J Prescott, Clive M Onnie, Sheila A Fisher, Jonathan Marchini, Jilur Ghori, Suzannah Bumpstead, Rhian Gwilliam, Mark Tremelling, Panos Deloukas, John Mansfield, Derek Jewell, Jack Satsangi, Christopher G Mathew, Miles Parkes, Michel Georges & Mark J Daly

abstract

Several risk factors for Crohn’s disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn’s disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls.

The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

LIST OF PARTICIPANTS

Legend: Coordinating PI Participants

	1	2	3	4	5	6	7	8	9	10	11	12	13
	BE-SMART	CEDAR-UC	Combined therapy of biologicals and new oral drugs.	DETECT	DNA banking	GENGISCAN	HELP-AID	I-CARE	Immunization	LOVE	PACIFIC	Pediatric	SPARE
AZ Damiaan	x										x		x
AZ Delta campus Wilgenstraat Roeselare	x	x				x	x				x		x
AZ Groeninge	x	x					x				x
AZ Maria Middelares		x									x
AZ Sint-Lucas Brugge	x												x
AZ Sint-Lucas Gent							x
AZ Turnhout campus Sint-Jozef							x
CHC Clinique Saint-Joseph - Liège	x			x			x
CHU de Liège site Sart-Tilman	x	x		x		x	x	x			x		x
CHU UCL Namur site Godinne		x	x			x			x		x		x
Clinique Saint-Jean							x
Clinique Saint-Pierre	x						x						x
Hôpital de Joliment			x	x					x	x
Hôpital Erasme	x	x		x	x	x	x	x			x		x
Imeldaziekenhuis	x	x		x				x			x		x
Mariaziekenhuis Noord-Limburg				x			x
Onze Lieve Vrouwziekenhuis campus Aalst	x	x					x				x
UZ Antwerpen							x
UZ Brussel												x
UZ Gent		x		x		x	x						x
UZ Leuven Gasthuisberg	x	x		x		x	x			x	x		x
Ziekenhuis Oost-Limburg campus Sint-Jan							x

	1	2	3	4	5	6	7	8	9	10	11	12	13
	BE-SMART	CEDAR-UC	Combined therapy of biologicals and new oral drugs.	DETECT	DNA banking	GENGISCAN	HELP-AID	I-CARE	Immunization	LOVE	PACIFIC	Pediatric	SPARE
Karen Van Hoeve
- -			x	x					x	x
Leila Amininejad		x			x		x
Saskia Appelmans
Filip Baert	x	x				x	x				x		x
Thomas Billiet
Patrick Bontems
Peter Bossuyt	x	x		x				x			x		x
Isabelle Bueres
Katrien Bulté
Guillaume Burnet
Peter Burvenich
Philippe Caenepeel
Olivier Cajot
Christophe Claessens							x
Jean-Charles Coche
Jean-Louis Coenegrachts
Arnaud Colard							x
Filip Couturier
Lara Crapé
Anneline Cremer						x		x
Cléo Croonen
Francois D'Heygere	x
Steven De Coninck
Elisabeth De Greef												x
Marc De Maeyer
Marc De Reuck
Elodie De Ruyck
Nicolas de Suray
Martine De Vos				x		x	x						x
Benedicte De Vroey
Stefan Delen
Marie-Armelle Denis
Pieter Dewint		x									x
Olivier Dewit	x						x						x
Sophie Dewit				x			x
Joris Dutre
Anke Engelen
Marc Etienne
Marc Ferrante	x	x		x			x						x
René Fiasse
Fernand Fontaine	x			x
Denis Franchimont	x			x		x	x				x		x
Silke François
Jeroen Geldof
Bruno Hauser
Pieter Hindryckx		x
Ilse Hoffman
Tom Holvoet
Alice Hoyois
Evelien Humblet							x
Saskia Ilegems
Aranzazu Jauregui Amezaga
Guy Lambrecht	x										x		x
Pierre Lammens
Claire Liefferinckx											x
Triana Lobaton
Edouard Louis				x		x	x				x		x
Elisabeth Macken							x
Marie-Christine Mairlot
Jean-Marc Maisin
Fazia Mana							x
Walter Margos
Fady Mokaddem
Kim Moubax
Vinciane Muls
Carmen Musala
Michele Ngassa
Maja Noman
Hanne Ooms
An Outtier
Romy Ouziel
Harald Peeters
Annelies Posen
Philippe Potvin
Lieven Pouillon
Jean-Francois Rahier		x	x			x			x		x		x
Catherine Reenaers	x	x						x
João Sabino
Caroline Saudoyer
Michael Schapira
Nathalie Schoofs
Nele Schoofs
Alexandra Sermeus
Francoise Smets
Michaël Somers
Dirk Staessen
Marjan Steppe
Beatrijs Strubbe							x
Jo Swinnen
Clara Thienpont
Marie Truyens
Haydeh Vafa
Gert Van Assche
Stephanie Van Biervliet
Frank Van De Mierop
Gaëtan Van Den Steen
Jurgen Van Dongen
Evi Van Dyck
Andre Van Gossum
Karen Van Hoeve
Philippe Van Hootegem	x												x
Catherine Van Kemseke
Wouter Van Moerkercke		x					x				x
Steven Van Outryve
Stijn Vanden Branden	x	x					x				x
Liv Vandermeulen
Jo Vandervoort
Gigi Veereman												x
Severine Vermeire						x				x	x
Annelies Verreth
Bram Verstockt
Sophie Vieujean
Francis Weyn
Barbara Willandt

	1	2	3	4	5	6	7	8	9	10	11	12	13
	BE-SMART	CEDAR-UC	Combined therapy of biologicals and new oral drugs.	DETECT	DNA banking	GENGISCAN	HELP-AID	I-CARE	Immunization	LOVE	PACIFIC	Pediatric	SPARE
Marc Aerts
Saskia Appelmans
Morgane Barbaraci
Christel Berben
Anne Bertrand
Karin Bevers
Ann Bommerez
Anne-Marie Borremans
Layla Boutaffala
Anja Brepoels
Deborah Callebert
Nathalie Chapelier
Annick Christiaens
Lieve Coekaerts
Emilie Collet		x	x			x			x		x		x
Marie Laure Cornet
Ann D'hondt
Christine De Becker
Elien De Cock	x	x				x	x				x		x
Els De Dycker
Evva De Jonckere	x	x				x	x				x		x
Liesbet De Meuter
Marijke De Wolf
Lien Decaesteker	x	x				x	x				x		x
Annick Deflandre
Goedele Dewitte
Christel Duchene
Isabelle Dury
Hanane El Amrite
Patricia Geens
Joline Goossens
Liesbeth Goossens
Jenny Heremans
Tine Hermans
Inge Huys
Anita Janssens
Wendy Janssens							x
Kathleen Kokke							x
Tessy Lambrechts
Melissa Lauwers
Geraldine Leonard
Anita Maltère
Julie Massart
Charlotte Minsart
Lislot Mommerency
Melissa Nigro
Ariane Paps
Karine Peters
Emilie Pontus
Joke Robrechts
Nele Rooryck
Pim Sansen
Caroline Saudoyer
Martine Seegers							x
Lynn Sioncke
Larissa Staelens	x												x
Marjan Steppe
An Sterckx	x	x					x				x
Niki Strobbe
Natalia Swietec
Julie Thijs
Christella Ukunda
Ils Van de Schoot	x	x		x				x			x		x
Greet Van den Eynde
Tanja Van Dessel
Frederika Van Dyck
Nina Van Heddegem		x									x
Stephanie Van Impe
Nele Van Waes
Marie-Anne Vandebos	x	x				x	x				x		x
Sandrine Vanden Bergh
Louise Vandenbroucke	x										x		x
Sofie Vanderhasselt	x			x		x	x				x		x
Nancy Vandermeeren
Veroniek Vandewalle
Sarah Vervloesem
Valerie Wambacq
Natascha Wouters

Scientific papers

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

LIST OF PARTICIPANTS